Taste 2 receptors in GtoPdb v.2023.1
نویسندگان
چکیده
Taste 2 receptors or Bitter taste (TAS2Rs) are G protein-coupled expressed in oral sensory cells and a variety of non-gustatory tissues. The ~25 human TAS2Rs share low amino acid sequence identities with other GPCR families classified as broadly tuned "generalist" numerous, chemically diverse bitter agonists, narrowly "specialist" very few activators, intermediately an average number specialized to interact defined activators [32]. functional receptor genes varies among species orthologues might not be functionally conserved. Due their expression various tissues, the signal transduction is complex. Some drugs such analgesic, anti-inflammatory, antibacterial compounds. specialist database BitterDB contains additional information on compounds [14].
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ژورنال
عنوان ژورنال: IUPHAR/BPS guide to pharmacology CITE
سال: 2023
ISSN: ['2633-1020']
DOI: https://doi.org/10.2218/gtopdb/f117/2023.1